The focus of research may be cardiovascular development, physiology, pathologies, epidemiology, medical therapeutics or surgical therapeutics, excluding research into cancers.
Candidates must hold a doctorate or equivalent qualification in medicine, science, pharmacy or veterinary medicine.
A jury of between six and eight French scientists selected the winning candidates: Professors Ziad Mallat (Chairman of the Jury), Gisèle Bonne, Damien Bonnet, Michel Desnos, Anne Eichmann, Rodolphe Fischmeister and Gervaise Loirand
Jury members
![](https://www.fondation-lefoulon-delalande.fr/wp-content/uploads/2022/02/zmallat-150x150.jpg)
Ziat Mallat
![](https://www.fondation-lefoulon-delalande.fr/wp-content/uploads/2022/02/Gisele-Bonne-150x150.jpg)
Gisèle Bonne
![](https://www.fondation-lefoulon-delalande.fr/wp-content/uploads/2022/02/telechargement-_5_-150x150.jpg)
Damien Bonnet
![](https://www.fondation-lefoulon-delalande.fr/wp-content/uploads/2022/02/servlet-150x150.jpg)
Michel Desnos
![](https://www.fondation-lefoulon-delalande.fr/wp-content/uploads/2022/02/eichman-photo-150x150.jpg)
Anne Eichmann
![](https://www.fondation-lefoulon-delalande.fr/wp-content/uploads/2022/02/rodolphe-fischmeister-640x960-1-150x150.jpg)
Rodolphe Fischmeister
![](https://www.fondation-lefoulon-delalande.fr/wp-content/uploads/2022/02/DSC3479_web-150x150.jpg)
Gervaise Loirand
Past
recipients
2021
- Rida Al Rifai
Pathophysiology of experimental dissecting aortic aneurysm during JAK2V617F positive myeloproliferative syndromes - Florian Alonso
Fibrillin-1: a new actor in angiogenesis, an exploration of its therapeutic potential for vascular repair - Louise Benarroch
Identification of genetic modifying factors in laminopathies affecting striated muscles - Pierre Bobin
Production of cardiac pseudo tissues derived from human induced pluripotent stem cells as a preclinical study model for Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) - Aurélien Bustin
Automatic extraction of sudden death risk markers combining black blood MRI of myocardial scars and artificial intelligence - Guido Caluori
Cardiac aging and induced remodeling in atrial fibrillation - Stéphane Camus
Efferocytosis and control of myocardial remodeling by macrophages - Victor Charpentier
Customized expandable balloon stent for pediatric and congenital heart disease - Damien Huzard
The importance of affective touch in the mechanisms of cardiac regulation by the vagus nerve: the role of ‘C-tactile’ sensory fibers in heart rate variability and regulation of social behaviors in models of autism. - Kanchan Kulkarni
A new method of pacing to prevent the development of ventricular tachyarrhythmias during chronic myocardial infarction - Mathieu Panel
Spatio-temporal study of neuroinflammatory remodeling during heart failure in mice - Barbara Ribeiro
High-throughput phenotyping of KCNH2 gene variants encoding the hERG cardiac potassium channel - Natalia Smirnova
Influence of humoral immunity on the vessel wall in transplant vasculopathy - Almudena Val Blasco
Sodium- and calcium-dependent proarrhythmic mechanisms in catecholaminergic ventricular tachycardias
2020
- Isabel Alves : The importance of modifying genetic factors and pleiotropy in (cardiac) rhythm disorders: an integrative approach to Brugada Syndrome
- Caroline Choquet : Decoding the ‘cardiac code’: identifying the molecular and cellular mechanisms directing the temporal and spatial specification of early cardiac progenitors in mice
- Pierre-Michaël Coly : The effects of hemodynamic forces in the formation and incorporation of extracellular vesicles by endothelial cells, and their potential role in atherosclerosis
- Emilye Hiriart : Complement cascade involvement in the cerebrovascular lesions of COL4A1/A2-related disorders
- Rima Kamel : Phosphodiesterase gene therapy for heart failure
- Ahmed Karoui : Study of the cardioprotective role played by NMRK2 kinase in NAD coenzyme synthesis as a response to myocardial ischemia/reperfusion stress
- Caroline Le Dour : The role of lipotoxicity in dilated cardiomyopathy resulting from LMNA gene mutations
- Nassim Mahtal : Study of the role played by Vasorin in the maintenance of pericytes and microcirculation
- Nawal Maissa : ‘On demand’ opening of the blood-brain barrier
- Marine Martinez : The role played by the conduction system on repolarization heterogeneity and ventricular fibrillation in a large mammal model of chronic infarction
- Anja Nitzsche : Modulation of the vascular protective signaling effect of sphingosine 1-phosphate
- Chloé Rafael : Involvement of the renal NaCl secretion pathway in the pathophysiology of hypertension
- Jairo Rodriguez-Padilla : Classification of electrical signals to guide arrhythmia ablation
- Nadine Suffee : Characterization of the atheroprotective mechanism of innate lymphoid cell type 2 (ILC-2)
2019
- Renée Chow : Study of the role played by mechanical forces induced by cardiac contraction during heart valve formation in zebrafish
- Guillaume Coutance : Optimizing the cost-effectiveness of endomyocardial biopsy in cardiac transplant recipients through the creation and validation of an individualized risk stratification tool for cardiac allograft rejection
- Audrey Desgrange : Deciphering the mechanisms behind asymmetric morphogenesis of the heart
- Thomas Hof : Study of TRPM7 (Transient Receptor Potential Melastatin 7) channel involvement in conditions related to cardiac electrical activity
- Claire Leclech : The influence of biophysical signals on the organization and functionality of a vascular endothelial cell monolayer
- Marta Lindner : The effects of FGF23 and αKlotho on the prevention of cardiovascular morbidity and mortality
- Stéphanie Paradis : The role of photobiomodulation in advance warning of intermittent hypoxia-induced myocardial injury via inhibition of Hypoxia-Inducible Factor-1
- Laetitia Pereira : O-GlcNAcylation of Epac as a novel regulator of cardiac Ca2+ signaling
- Antoine Rimbert : Identification of new regulatory mechanisms governing plasma LDL-Cholesterol levels
Research grant renewals :
- Emilie Dubois-Deruy : Regulatory mechanisms associated with superoxide dismutase 2 in heart failure: the involvement of acetylation
- Icia Santos-Zas : Exploration and modulation of CD8+ T cells in postinfarction cardiac remodeling
2018
- Sophie Burel : Phosphorylation and FGF13: Roles in Cardiac NaV1.5 Channel Regulation
- Emilie Dubois-Deruy : Regulatory mechanisms associated with superoxide dismutase 2 in CI: the involvement of acetylation
- Anne-Laure Duchemin : The role played by hemodynamic forces during ventriculobulbar valve morphogenesis in zebrafish
- Emilie Faure : Study of the role played by krox20 factor in aortic valve endothelial cells and study of the role played by hemodynamics in valve degeneration
- Bamba Gaye : The therapeutic potential of non-coding RNAs and their use as biomarkers in vascular pathologies such as abdominal aortic aneurysm (AAA)
- Youmna Ghaleb : Identification of new genes in Familial Hypercholesterolemia using next-generation sequencing
- Edyta Glogowska : The role played by Piezo1 in pulmonary hypertension
- Nicole Karam : The influence of gender on survival following ischemic cardiac arrest
- Peter Langfield : Assessment of arrhythmogenic risk as a result of repolarization heterogeneity in patient-specific models
- Marianna Meo : Spatio-temporal analysis of the heart’s electrical signals for atrial fibrillation ablation
- Alice Recalde : New therapeutic targets in atrial fibrillation: the role played by Epac
- Baptiste Rode : New therapeutic targets in atrial fibrillation: the role played by Epac
- Icia Santos-Zas : Exploration and modulation of CD8+ T cells in post-ischemic cardiac remodeling
Research grant renewals :
- Laetitia Andrique : 3D modeling of artificial vessels: an appropriate tool for analysis of vasculogenesis
- Silvia Bottini : Investigation of a novel genomic function of the Ro60/s-RNY ribonucleoprotein complex in foamy macrophages
- Thomas Mathivet : A window on vascular pathologies: study of vascular dynamics using in vivo multiphoton imaging
2017
- Laetitia Andrique : In vitro production of mature blood vessels using 3D vascular tissue engineering
- Claire Angebault : Involvement of the sarcotic/endoplasmic reticulum – mitochondria interaction in Duchenne Muscular Dystrophye
- Feriel Azibani : Late anthracycline-related cardiotoxicity in pregnancy and postpartum
- Daria Bonazzi : Study of the role played by membrane tension in regulation of the cellular response during meningococcal infection
- Silvia Bottini : Functional characterization of the Ro60/s-RNY ribonucleoprotein complex in foamy macrophages
- Pedro Campinho : Endothelial cell dynamics and tissue mechanics during dorsal aorta development
- Romain Capoulade : Pathophysiology of mitral valve prolapse: multi-modality imaging, animal model and genetics
- Rachel Climie : The predictive value of baroreflex sensitivity for cardiovascular incident events in the general population
- Fabienne Lescroart : Defining the cellular and molecular heterogeneity of cardiac progenitors during murine embryogenesis
- Thomas Mathivet : A window on pathological vasculature: the use of multiphoton technology for in vivo murine imaging. Stroke and hereditary vascular diseases HHT and ehlers danlos syndrome (vEDS)
- Gleb Novikov : The molecular mechanisms of the AT1R response to mechanical stimuli, the role of sodium and identification of new therapeutic targets
Renouvellements de bourse :
- Fabrice Antigny : Potassium channel KCNK3 involvement in the development of pulmonary hypertension. An assessment of the relevance of therapeutics in targeting the KCNK3 channel
- Grégory Franck : The mechanisms involved in atherosclerotic plaque erosion processes. The role of netosis and the MRP8/14 complex in a new model of erosion in mice
- Florence Tatin : The role of apelin at intercellular junctions and immune cell recruitment in the lymphatic endothelium
2016
- Fabrice Antigny : Potassium channel KCNK3 involvement in the development of pulmonary hypertension. An assessment of the relevance of therapeutics in targeting the KCNK3 channel
- Caroline Cros : The role of Left Atrial Electro-Structural Remodeling Heterogeneity in Persistent Atrial Fibrillation in a Large Mammal Model
- Thibaut Duparc : In vivo deletion of the IF1 protein: its involvement in lipoprotein metabolism and the development of atherosclerosis
- Grégory Franck : The mechanisms involved in atherosclerotic plaque erosion processes. The role of NETosis and the MRP8/14 complex in a new model of erosion in mice
- Laurent Gamba : The role played by the JNK pathway in zebrafish (Danio rerio) heart regeneration
- Koïchi Kato : Study of SAP97 protein variants in Brugada syndrome
- Lisa Kitasato : The mechanism of action of Angiomotin-like1 (Amot11) in the regulation of cardiomyocyte proliferation
- Soazig Le Guyon : The use of a murine model of endovascular prosthesis infection to test new antibiofilm molecules
- Delphine Mika : Regulation of cardiac pacemaker function by PDE4-encoded isoforms
- Mélanie Paillard : The structural and functional role of mitochondria-reticulum interactions during ischemia-reperfusion and cardioprotection
- Thibaut Quillard : The molecular and epigenetic mechanisms of arterial heterogeneity and vascular calcifications
- Caroline Roney : The Effects of Variability in Pulmonary Vein Electrophysiology and Fibrosis on Arrhythmia Sensitivity and Dynamics
- Angelo Torrente : The importance of Ca2+ dynamics in the pacemaker mechanism of the sinus node; the role of L-type calcium channels in cyclic AMP synthesis and conduction through the sinus node
Renouvellements de bourse :
- Brahim Belbellaa : Preclinical development of an innovative in vivo gene therapy protocol for the treatment of cardiomyopathy associated with Friedreich’s ataxia, and studies of pathophysiological mechanisms and biomarkers associated with a cellular deficit or excess of the protein Frataxin
- Loubina Fazal : Inhibition of Epac1 and its cardioprotective effect in ischemia/reperfusion in mice
2015
- Alban Baruteau : The characteristics of Rhythm and Conduction Disorders Associated with Congenital Heart Disease involving Atrioventricular DISCOrdance
- Jason Bayer : Low-intensity extended surface stimulation (WAYLESS): a new therapy to end lethal cardiac arrhythmias
- Amandine Cartier-Michaud : Modulation of vascular functions by inhibiting intracellular CD146 interactions
- Charlotte Erpicum : The role played by the lymphatic system in cardiovascular pathologies
- Loubina Fazal : The effects of Epac1 inhibition in a murine ischemia/reperfusion model
- Rebecca Gentek : Self-renewal of resident macrophages as a critical factor for cardiac regeneration
- Kateryna Kyrylkova : Biological role of a stress-response gene Pw1/Peg3 in cardiac physiology
- Emelyne Lecuyer : Study of the cholesterol-lowering function of human gut microbiota in a murine model of atherosclerosis
- Daniel Romero : Optimization of risk stratification and new therapeutics for subjects with from Brugada syndrome: the development and validation of new tools based on signal processing techniques, mathematical modeling and simulation
- Pierre Sicard : The roles played by of Gadd45 y in heart failure
- Grace Thomas-Noguera : Functional characterization of SLC44A2, a new gene associated with Venous Thrombosis
Renouvellement de bourse
- Nicolas Diguet : The role of Angiomotin-like1 (Amotl1) in the regulation of cardiomyocyte proliferation
- Adèle Faucherre : Study of the role of the Piezo1b mechanosensitive ion channel during cardiogenesis in zebrafish
- Julie Favre : Novel role of the estrogen receptor Erα in flow-dependent dilation of resistance arteries: the importance of membrane signaling
- Sarah Karam : Overexpression of a phosphodiesterase-4 to prevent heart failure and arrhythmias
2014
- Julien Barc : The genetics and pathophysiology of sudden cardiac death: new approaches
- Richard Bayles : Erythrophagocytosis and Atherosclerosis
- Frédéric Boal : The role played by phosphatidylinositol 5-phosphate (PtdIns5P) in cardiac remodeling: therapeutic perspectives
- Aline Chevallier : The roles played by sphingosine-1-phosphate in retinal angiogenesis
- Adèle Faucherre : Study of the role played by the mechanically activated Piezo2a ion channel during cardiogenesis in zebrafish
- Julie Favre : Novel role of the estrogen receptor Erα in flow-dependent dilation of resistance arteries: the impact in aging
- Kiave Yune Ho Wang Yin : Inflammatory factors and post-ischemic cardiac remodeling
- Sarah Karam : Overexpression of a phosphodiesterase-4 to prevent heart failure and arrhythmias
- Olivia Lenoir : An exploration of the determinants and role played by endothelial autophagy in hypertensive heart disease and nephropathy
- Mariana Mirabel : Myocardial involvement in acute rheumatic fever: an assessment using modern imaging and immunology techniques
- Emanuela Repetto : An exploration of the emerging world of non-coding RNAs as novel functional mediators and biomarkers for atherosclerosis
- Sonia Stefanovic : Unraveling the genetic and epigenetic signature of myocardial lineages in the venous pole region
- Florence Tatin : Molecular mechanisms regulating valve formation in the vascular system and their dysfunction in association with obesity
- Elsa Vanhecke : GLP-1 and angiogenesis: diabetic retinopathy and safety of diabetes treatment
- Mariana Varna : Nanosystems for thrombolytic therapy
Renouvellement de bourse
- Pierre Joanne : Development of a cellularized biomaterial consisting of collagen nanofibers and cardiac progenitors for the treatment of heart failure
2013
- Brahim Belbellaa : Développement d’une stratégie innovante pour le traitement de l’ataxie de Friedreich par thérapie génique in vivo à l’aide de vecteur viraux recombinant AAV
- Karim Belmokhtar : Rôle du Récepteur aux AGEs (RAGE) dans l’apparition des calcifications vasculaires Urémiques
- David Benoist : Origines anatomiques et mécanismes responsables d’arythmies ventriculaires dans l’insuffisance cardiaque droite
- Brunella Cristofaro : Molecular specification of collateral arteries formation
- Joana Raquel Delgado Martins : Sensing pressure with ion channels: role of piezo 1 in arterial mechanotransduction
- Ji Gao-Desliens : Développement du premier inhibiteur de l’aminopeptidase A actif par voie orale, comme agent antihypertenseur à action centrale
- Simon Guiraud : Pathophysiologie de l’atteinte cardiaque et vasculaire chez des souris HANAC Col4a1
- Pierre Joanne : Mise au point d’un biomatériau cellularisé constitué de nanofibres de collagène et de progéniteurs cardiaques pour le traitement de l’insuffisance cardiaque
- Mathilde Keck : Canal calcique ORAI3 dans le cardiomyocite normal et hypertrophié
- Julie Lafaurie-Janvore : Rôle du Complexe LINC dans la Mécanotransduction des Cellules Endothéliales
- Laeticia Lichtenstein : Caractérisation du récepteur P2Y13 dans le développement de l’athérosclérose
- Thomas Joseph Moore-Morris : Endocardial cell fate decisions underlying congenital valve defects
- Gaëlle Odelin : Modèle murin de valvulopathie : étude du rôle du gène Krox20 dans le développement des valves cardiaques
- Julien Viaud : Rôle des GTPases de la famille Rho et des phosphoinositides dans la genèse des plaquettes sanguines
Renouvellements de bourse :
- Ana Llach Martinez : Implication de la protéine Epac dans les altérations du calcium intracellulaire et arythmies
- Eloi Marijon : Dépistage Familial systématique en cas de Mort Subite : Application en population
2012
- Dong Broqueres-You : Post-ischemic neovascularization and guidance molecules: the role of nervous system restoration in the presence of diabetes
- Caroline Desmetz : Inflammation and atherosclerosis: the repertoire and functions of arterial wall resident B cells during human atheromatous disease
- Virginie Deswaerte : Immunomodulation of cholesterol metabolism and the impact on atherosclerosis
- Fabio Fernandes Rosa : The genetics of primary hyperaldosteronism
- Nathalie Gaborit : Age-related cardiac conduction abnormalities: roles of Iroquois transcription factors in congenital heart diseases-associated arrhythmias
- Stéphanie Gayral : The role played by phosphoinositide 3-Kinase Cllα in smooth muscle cells: is there involvement in arterial wall pathologies?
- Anne Leclercq : Study of the role played by endothelial cells in thoracic aortic aneurysmal lesions
- Ana Llach Martinez : The involvement of Epac in intracellular calcium alterations and arrhythmias during heart failure
- Laurine Marger-Marienne : Study of the differentiation of adult muscle stem cells into pacemaker myocytes: towards a cell therapy for cardiac automatism disorders
- Eloi Marijon : Routine Family Screening for Sudden Cardiac Death: Application in the population
- Ludovic Martin : Identification of the Nav1.5 sodium channel intracellular regulatory pathways: the therapeutic impact for cardiac arrhythmias
- Antoine Muchir :
- *Study the integrity of the nuclear envelope as a key mediator of MAP kinases activation
- *Identify and evaluate molecular determinants of cardiac dysfunction in pathologies of the nuclear envelope
- *Identify novel therapies for the cardiac pathologies of nuclear envelope
- Catherine Yzydorczyk : The involvement of hemodynamics and arterial oxygen pressure in the induction of ectopic mineralization
Research grant renewals :
- Delphine Ciais : Identification of those BMP9/BMPR2 targets involved in the pathophysiology of pulmonary hypertension
- Céline Mias : The role played by the ephrin-B1 protein in cardiac tissue aging
2011
- Chiara Alfarano : The role played by apelin in myocardial energy remodeling: pathophysiological aspects and therapeutic perspectives
- Delphine Ciais : Identification of those BMP9/BMPR2 targets involved in the pathophysiology of pulmonary hypertension
- Nathalie Clément : Defining those signaling pathways downstream of AC8 that lead to the migration of VSMCs in an inflammatory context
- Zeineb Es-Salah-Lamoureux : The hERG cardiac potassium channel: from biophysics to therapeutics
- Sophie Gilibert : The role played by the SR-BI receptor in the endothelial cell: involvement in the development and regression of aherosclerotic plaque
- Jean-François Le Garrec : Quantitative analysis of cardiomyocyte polarity and modeling of cardiac chamber formation
- Xavier Loyer : Endothelial regulation of microRNAs in vitro and in vivo by trimming and oxidized LDLs: a potential role in atherosclerosis
- Maria Machado : Endothelial regulation of microRNAs in vitro and in vivo by trimming and oxidized LDLs: a potential role in atherosclerosis
- Céline Mias : The role played by the ephrin B1 protein in cardiac tissue aging
- Maryline Moulin : The involvement of the mitochondrial permeability transition pore in early pathophysiological mechanisms of cardiovascular pathologies
- Marie Rouanet-Gueguen : N
- New roles of PARs (Proteinases-Activated Receptors) in vascular biology
- Sonia Séverin : Mechanisms controlling platelet formation and activation: the role of class III Pl3K, Vps34 and its product Ptdlns3P
- Richard Walton : Purkinje fibers as a radiofrequency ablation target for sudden cardiac death prevention
Research grant renewals:
- Stéphane Doly : Serotonin 5-HT2B receptors and valvulopathy thrombose: application to cardiovascular pathology
- Cristina Espinosa Molina : The role played by phosphodiesterases (PDEs) in the vulnerability of human atria to the development of atrial fibrillation
2010
- Elise Belaidi : The role played by cyclophilin D in protecting against myocardial ischemia-reperfusion: between mitochondrial permeability transition and reticulum stress
- Stéphane Doly : Serotonin 5-HT2 receptors and valvulopathy
- Cristina Espinosa Molina : The role played by phosphodiesterases type 4 (PDE4) in cAMP, and by calcium dynamics in atrial fibrillation
- Gilles Kauffenstein : The role played by extracellular nucleotides in the local regulation of vascular tone and remodeling
- Claire Crola-Da Silva : The little-known role of cardiac fibroblasts in protecting the heart during infarction. Study using a cardiomyocyte model in co-culture
- Pauline Parisot : The genetic and cellular basis of coronary artery development: involvement of the second heart field
- Cathy Quemener : Study of the roles and mechanisms of action of CXCL4, CXCL4L1 and CXCL4 mutants in vascular development
- Kevin Retailleau : Filamin A and arterial mechanotransduction
Research grant renewal :
- Cara Büsst : The role played by L-WNK1 in regulating ion transport in the distal nephron
2009
- Magali Berthouze : Β-adrenergic receptors and the cardiac pathophysiology of Epac
- Isabelle Brunet : Dynamic study of neurovascular interactions during murine development
- Cara Büsst : The role played by L-WNK1 in regulating ion transport in the distal nephron
- Matthias Canault : Identification of a process to improve the preservation of platelets for transfusion at 4°C. An assessment of the role played by CD40 ligand (CD40L) in the propagation and amplification of the prothrombotic inflammatory state in coronary artery disease.
- Claire Crola-Da Silva : The little-known role of cardiac fibroblasts in protecting the heart during infarction. Study using a cardiomyocyte model in co-culture
- Nadjia Kachenoura : A comparative study of cardiac CT and stress ultrasound in patients with suspected acute coronary syndrome: developments, contributions and validations of new quantitative image processing analysis methods
- Alexandre Marchand : The role played by calcium in cardiovascular remodeling: the involvement of microRNAs in cardiovascular pathologies and a study of new therapeutic targets
- Benjamin Richard : Nexin-1 protease and heart failure
- Soraya Taleb : The role played by SOCS3 in immune response modulation and the development of atherosclerosis
- Florence Teillet : Structural studies of Soluble Guanylate Cyclase, a key cardiovascular system enzyme
Research grant renewals:
:
- Frédéric Adam : The molecular and cellular mechanisms of JNK1 and JNK2 mitogen-activated protein kinases in thrombosis: application to cardiovascular pathology
- Cécile Fligny : The role played by tissue transglutaminase in the progression and regression of renal and myocardial collagenous fibrosis in response to hypertensive stress
2008
- Frédéric Adam : The involvement of Mitogen-Activated Protein Kinase JNK1 in the pathophysiology of hemostasis and thrombosis
- Abeer El Wakil : The impact of mechanisms controlling functional zonation of the adrenal cortex on the pathophysiology of hypertension
- Cécile Fligny : The role played by tissue transglutaminase in the progression and regression of renal and myocardial collagenous fibrosis in response to hypertensive stress
- Jean-Marc Hyvelin : Intrastent myointimal hyperplasia: the effect of heme oxygenase-1 induction
- Ana Pena Ruiz : An exploration of the influence of polymorphism *2 of the gene encoding cytochrome 2C19 on the response to clopidogrel in young coronary patients (AFIJI Cohort): the CLOVIS 2 study
- Nathalie Sabaa-Mettoudi : RNA interference control of embryonic and pathological angiogenesis
- Yannis Sainte Marie : Study of the role played by NOS1 in cardiac contractile function and arrhythmia occurrence in a model of myocardial infarction v
- Kyoji Urayama : Does PKR1 invalidation in the epicardium have adverse cardiovascular consequences ?
Research grant renewal:
- Nathalie Beaufort : The role played by endogenous and microbial proteolytic activities as determinants of fibrinoid vegetation fragmentation and tissue destruction in infective endocarditis
- Violaine Griol-Charhbili : The role played by aldosterone in cardiovascular function: the effect of endothelial mineralocorticoid receptor overexpression
2007
- Constandina Arvanitis : Characterization of the molecular mechanisms involved in regulating catecholanin release at the neurocardiac synapse: defining the inhibitory role of the a2-adrenergic system
- Nathalie Beaufort : The role played by endogenous and bacterial proteolytic activities as determinants of fibrinoid vegetation frangmentation and tissue destruction in infective endocarditis
- Caroline Cieniewski-Bernard : Towards the characterization of new markers for post-infarction left ventricular remodeling
- Violaine Griol-Charhbili : The role played by aldosterone in cardiovascular function: the effect of endothelial mineralocorticoid receptor overexpression
- Valérie Perrot : Rho protein exchange factors as novel targets of therapeutic interest in arterial hypertension
- Francesca Rochais : Characterization of factors involved in the regulation of cardiac progenitor cell fate during development
- Marcela Szopos : Mathematical modeling of the influence of aortic arch geometry on blood pressure.
Research grant renewal :
- Mélanie Eyries : Quantification of angiogenesis using automatic image analysis.
- Stéphanie Michineau : The involvement of the P13-kinase/Akt pathway in aneurysmal stabilization
2006
- Nicolas Elie : Quantification de l’angiogenèse par analyse automatique d’images.
- Mélanie Eyries : Implication de la voie de signalisation des Bone Morphogenetic Proteins dans la physiopathologie de l’hypertension artérielle pulmonaire.
- Caroline Fribourg : Study of VWF binding to OPG and identification of the VWF domain responsible for this binding; the role played by VWF in regulating OPG levels, and the consequences of decreased OPG levels in VWF-deficient mice.
- Socorro Vanesca Frota Madeira : Are PPARs essential mediators in activatiing endothelial NO synthase in response to physiological agonists and plant polyphenols ?
- Witold Kilarski : Comparative profiling of endothelium proteome in normal and granulation tissue vasculature.
- Stéphanie Michineau : The involvement of the P13-kinase/Akt pathway in aneurysmal stabilization.
- Catherine Plin : The effect of GSK-3ß protein on myocardial ischemia-reperfusion-induced mitochondrial permeability transition pore opening
- Marcela Szopos : Mathematical modeling of the influence of aortic arch geometry on blood pressure.
Research grant renewal :
- Xavier Houard : The role played by proteolysis in the progression of degenerative vascular pathologies
2005
- Carole Devaux : Characterization of the CRP-LXR pathway in human vascular smooth muscle cells: involvement in arterial remodeling processes.
- Meyer Elbaz : Evolution of the Non-Stenotic Lesions Responsible for Acute Coronary Syndrome: study conducted using Endocoronary ultrasound
- Lars Erdtmann : Hepatitis C virus NS2 protein induces myocarditis in a transgenic mouse model.
- Xavier Houard : The role played by proteolysis in the progression of vascular pathologies.
- Elizabeth A.V. Jones :
-The creation of blood vessels using microfluidic pumps
-Direct observation of arteriovenous malformations by videomicroscopy in genetically modified murine embryos. - Jérôme Leroy : The role of type 4 phosphodiesterases in heart failure.
- Caroline Pinet : The mechanism of action of thrombin on cardiac sodium channels.
- Anne Pizard : The kallikrein-kinin system, peptidergic vasodilatation and vascular diseases.
Research grant renewal :
- Marianne Abi Fadel : Characterization of the role of the PCSK9 gene in the pathophysiology of familial hypercholesterolemia and its cardiovascular complications
2004
- Marianne Abi Fadel : Characterization of the role of the PCSK9 gene in the pathophysiology of familial hypercholesterolemia and its cardiovascular complications.
- Céline Fassot-Lucht : Study of the aortic transcriptome. Research into the determinants of arterial stiffness. tude du transcriptome aortique. Recherche des déterminants de la rigidité artérielle.
- Jeanne Flavigny : Overexpression of human NOS1 in mice: the impact o contractility and calcium movement.
- Claudine Menard : Preclinical study of heart failure using cell therapy.
- Eric Morel : The role played by the (cAMP-activated) Epac exchange factor in cardiac hypertrophy and heart failure.
- Mylène Potier : Reendothelialization mechanisms: the role of osteopontin in estrogen action.
- Radia Tamarat : Analysis of the effects on renal tissue of targeted MR overexpression, specifically in vascular cells.
Renouvellements de bourses :
- Fanny Bajolle : The involvement of the anterior heart field in the morphogenesis of the murine heart efferent pathway.
- Nathalie Lalevee-Girard : Electrophysiological study of cardiac activity in Drosophila during development.
2003
- Carole Amant : Study of Hypoxia-Induced Factor-1 stabilization and activation by phosphorylation: clinical applications and gene therapy of angiogenesis and cardiac and peripheral ischemia.
- Fanny Bajolle : Morphogenesis of the efferent pathway (aorta and pulmonary trunk) in the murine heart.
- Olivier Blanc-Brude : Survivin in atherosclerosis.
- Angelika de Bree : Folate, choline and betaine intakes and cardiovascular diseases.
- Ariane Galaup : Molecular mechanisms of angiogenesis: the role played by ANGPTL-4 in physiological and pathological angiogenesis.
- Nathalie Lalevée-Girard : Functional cardiogenesis in Drosophila: an electrophysiological study.
- Nathalie Petit : Pathophysiological mechanisms of cavernous angiomas
- Béatrice Thomas : Study of the molecular phenotype of the pathological endothelial cell: application to inherited vascular diseases
Research grant renewals :
- Sophie Creuzet : The neural crest and the cardiovascular system.
- Nermine Lila : HLA-G expression and heart transplantation in humans.
2002
- Onnik Agbulut : Adult stem cell transplantation in the treatment of heart failure
- Sébastien Alcolea : The distribution and addressing mechanisms of KvLQT1 potassium channels in the human heart.
- Olivier Barbier, Ph. D : PPARa activators induce the expression of UDP-glucuronosyltransferases metabolizing liquid mediators of inflammation – the anti-inflammatory role played by lipid-lowering fibrates.
- Giuseppina Caligiuri : The role played by immunity in arterial remodeling.
- Sophie Creuzet : The neural crest and cardiovascular system.
- Pascal Drane : Dysfunction of nuclear receptor transactivation mechanisms causing neurological and cardiac deficiencies: the SP/CS model.
- Barbabas Gellen : Role of serca over expression in the time course of left ventricular remodelling following myocardial infarction in rats.
- Nermine Lila : HLA-G expression and heart transplantation in humans.
- Laurence Mabile : Hormonal and nutritional mechanisms regulating hepatic lipase expression in humans.
- Gunsel Canan Nebigil-Desaubry : Involvement of the serotonin 5-HT2B receptor in cardiomyopathy.
2001
- Salia Cherifi : Study of the physicochemical and magnetic properties of small systems using an innovative microscopy technique: photoelectric effect microscopy (PEEM), and the development of instrumentation to improve its spatial resolution.
- Marie-Claude Clochard : Study of the beneficial effects in medicine of the radiochemical grafting of peptides onto a biodegradable polymer substrate.
- Bruno Delorme : Muscle stem cells for cardiac cell therapy.
- Julien Ghislain : Identification of those elements controlling the expression of the Krox20/Egr2 transcription factor that plays an essential role in the development of vertebrate central and peripheral nervous systems.
- Abdeslem Hallou : Control of primary bioradical mechanisms: new contributions to pathophysiology and therapeutics.
- Matteo Elia Mangoni : Physiopathology of the cardiac rhythm.